Etodolac has been conjugated with different antioxidants having antiulcerogenic activity with the objective of obtaintingEtodolac ââ?¬â??antioxidant mutual prodrugs as safer NSAIDs devoid of ulcerogenic side effects.SynthesizedPurified prodrugswere characterized by m.p., TLC, elemental analysis, FTIR, NMR and MS. The synthesized derivatives are screened for their anti-inflammatory ,analgesic and antiulcer activity. The biological evaluation of mutual prodrugsshowed retention of anti-inflammatory activity withreduced ulcerogenic side effects. The masking of parent drug in mutual prodrug of etodolac resulted in less exposure to gastric mucosa. The results indicated that Etodolac ââ?¬â??antioxidant mutual prodrugs have the potential to be developed as safer gastrosparing NSAIDs.
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